COMPARATIVE IMMUNOMORPHOLOGICAL ANALYSIS OF ASTROCYTES AND NEUROCYTES OF THE CEREBELLAR GRAY MATTER IN RATS INFLUENCED BY THE FOOD ADDITIVES COMPLEX

Neurological diseases are among the most common in Ukraine, especially given development of technology food industry and accelerated pace life, which contributes to an increased number additives nutrition products. The cerebellum is easily affected by adverse effects. Our research aimed conduct a comparative analysis immunomorphological changes astrocytes with neurons cerebellar gray matter rats at different periods consuming additives, namely monosodium glutamate (food additive E621), ponceau 4R E124) sunset yellow E110), using glial acid fibrillar protein NeuN-immunoreactivity reaction. White were used this study. We applied immunohistochemical marker GFAP establish protoplasmic astrocytes, paraffin sections for Neun-immunoreactivity Student's T-criterion was compare quantitative values dual series. difference considered reliable p<0.05. As result study, histological specimens demonstrated GFAP-positive cells large perikaryon numerical processes, we identified as NeuN-positive piriform structures, from whose narrowed apex 2-3 dendrites radiated molecular layer, latter turn gave numerous branches. these or Purkinje cells. Experimental studies have shown that both white cerebellum, there compensatory adaptive processes partial restoration structural components structures play decisive role process framework. Furthermore, morphometric study found dynamics experiment, average ganglion layer cortex experimental groups (from 1 5) significantly p˂0.05 compared control group animals.